GIVINOSTAT HYDROCHLORIDE HYDRATE

GIVINOSTAT HYDROCHLORIDE HYDRATE

Application

Givinostat hydrochloride hydrate has been used as a histone deacetylase inhibitor to test its effect on the human immunodeficiency virus reactivation in CD4+ T-cell model.

Biochem/physiol Actions

Givinostat is known to mediate the reduction of the human immunodeficiency virus release in macrophages.

Givinostat (ITF2357) is a hydroxamate HDAC inhibitor that inhibits class I and class II enzymes. Givinostat posseses a very promising activity profile in multiple myeloma and acute myelogenous leukemia in vitro and in vivo. Givinostat also has anti-inflammatory activity and inhibits the secretion of the tumor necrosis factor-alpha (TNF-α), IL-1, and IL-6. Givinostat has been in multiple Phase 2 studies for both inflammatory diseases (Duchenne Muscular Dystrophy , Juvenile arthritis, Polycythemia Vera) and blood cancers (myelomas and lymphomas).

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3575363 GIVINOSTAT HYDROCHLORIDE HYDRATE white to beige 100 SIGMA-ALDRICH −20°C DMSO: 20 mg/mL, clear powder ≥95% (HPLC)
£671.36 (exc VAT) per 25MG
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3575364 GIVINOSTAT HYDROCHLORIDE HYDRATE white to beige 100 SIGMA-ALDRICH −20°C DMSO: 20 mg/mL, clear powder ≥95% (HPLC)
£189.43 (exc VAT) per 5MG
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