BETA-ODAP

BETA-ODAP

Biochem/physiol Actions

β-ODAP is a potent inhibitor of HIF-prolyl hydroxylase-2 (PHD-2) that induces HIF dependent HRE (hypoxia response element) in normoxic conditions. β-ODAP is an analog of glutamic acid present in Lathyrus sativus (grass pea) that activates AMPA receptors. β-ODAP causes neurolathyrism upon prolonged consumption of L. sativus seeds.

?-ODAP is considered more neurotoxic than ?-ODAP, thus during food processing, its conversion to ? isomer is essential. ?-ODAP exhibits its neurotoxicity via the activation of metabotropic glutamatergic receptor.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level InChI key InChI Manufacturer Form Assay Price
3575441 BETA-ODAP white to beige 100 NEEQFPMRODQIKX-REOHCLBHSA-N 1S/C5H8N2O5/c6-2(4(9)10)1-7-3(8)5(11)12/h2H,1,6H2,(H,7,8)(H,9,10)(H,11,12)/t2-/m0/s1 SIGMA-ALDRICH powder ≥98% (HPLC)
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3575442 BETA-ODAP white to beige 100 NEEQFPMRODQIKX-REOHCLBHSA-N 1S/C5H8N2O5/c6-2(4(9)10)1-7-3(8)5(11)12/h2H,1,6H2,(H,7,8)(H,9,10)(H,11,12)/t2-/m0/s1 SIGMA-ALDRICH powder ≥98% (HPLC)
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