Ciproxifan maleate, >=98% (HPLC), powder

Ciproxifan maleate, >=98% (HPLC), powder

Application

Ciproxifan maleate has been used as a selective H3R antagonist to investigate the antidepressant potential of ciproxifan in chronic unpredictable stress (CUS) model of depression in mice. It has also been used as an H3R antagonist to develop in vivo receptor occupancy assay for histamine H3receptors (H3R)/to determine the occupancy of exogenous H3R antagonists using non-radiolabeled GSK189254 as a tracer in the rat.

Biochem/physiol Actions

Potent, selective H3 histamine receptor antagonist.

Cyclopropyl 4-(3-(1H-imidazol-4-yl)propyloxy)phenyl methanone (Ciproxifan) is a species-specific histamine H3receptor (H3R) inverse agonist. It is mainly used as a reference H3R antagonist in rodent models for neurological diseases, Alzheimer?s disease, attention deficit hyperactivity disorder (ADHD), and sleep-wake disorders.It can block monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B) enzyme isoforms reversibly in humans and rats.

Features and Benefits

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level InChI key InChI Manufacturer Solubility Form Assay Price Quantity
3573322 Ciproxifan maleate, >=98% (HPLC), powder white to beige 100 RLQFKEYRALXXEJ-BTJKTKAUSA-N 1S/C16H18N2O2.C4H4O4/c19-16(12-3-4-12)13-5-7-15(8-6-13)20-9-1-2-14-10-17-11-18-14;5-3(6)1-2-4(7)8/h5-8,10-12H,1-4,9H2,(H,17,18);1-2H,(H,5,6)(H,7,8)/b;2-1- SIGMA-ALDRICH DMSO: 32 mg/mL, H2O: insoluble powder ≥98% (HPLC)
£702.00 (exc VAT) per 25MG
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3573323 Ciproxifan maleate, >=98% (HPLC), powder white to beige 100 RLQFKEYRALXXEJ-BTJKTKAUSA-N 1S/C16H18N2O2.C4H4O4/c19-16(12-3-4-12)13-5-7-15(8-6-13)20-9-1-2-14-10-17-11-18-14;5-3(6)1-2-4(7)8/h5-8,10-12H,1-4,9H2,(H,17,18);1-2H,(H,5,6)(H,7,8)/b;2-1- SIGMA-ALDRICH DMSO: 32 mg/mL, H2O: insoluble powder ≥98% (HPLC)
£235.39 (exc VAT) per 5MG
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