Tavaborole

Tavaborole

Biochem/physiol Actions

Tavaborole (AN2690) is a potent antifungal that targets the post-transfer editing site of leucyl-tRNA synthetase (LeuRS). Tavaborole forms a covalent adduct with the 3′ adenosine of tRNA(leu) at the editing site of fungal, but not bacterial LeuRS, locking the enzyme in an inactive conformation. Tavaborole was recently approved for the treatment of onychomycosis of the toenail in adults.

General description

Tavaborole is a boron-based pharmaceutical agent. It has broad-spectrum oxaborole antifungal activity. Due to its low molecular weight, it facilitates maximal nail plate penetration than its predecessors.

Packaging

10, 50 mg in glass bottle

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Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Assay Price
3574624 Tavaborole white to beige 100 SIGMA-ALDRICH −20°C DMSO: 20 mg/mL, clear powder ≥95% (HPLC)
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3574625 TAVABOROLE white to beige 100 SIGMA-ALDRICH −20°C DMSO: 20 mg/mL, clear powder ≥95% (HPLC)
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