AP39

AP39

Biochem/physiol Actions

AP39 is a anethole dithiolethione (ADT-OH)-derivatized hydrogen sulfide (H2S) donor with a lipophilic & positively charged triphenylphosphonium (TP) moiety for mitochondrially targeted H2S release. AP39 stimulates mitochondrial electron transport and cellular bioenergetic function, protecting against mitochondrial DNA damage and cell death upon oxidative stress induction (effective conc. 30–100 nM; bEnd.3 cells). AP39 in vivo efficacy (0.1-1 µmol/kg i.v.; 0.1-0.3 mg/kg i.p.) is demonstrated in varous rodent models, including neurological damage post cardiac arrest, renal injury post ischemia-reperfusion, burn-caused organ damage, as well as brain atrophy in APP/PS1 mice.

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Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3576245 AP39 white to dark orange SIGMA-ALDRICH −20°C DMSO: 2 mg/mL, clear powder ≥95% (HPLC)
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3576246 AP39 white to dark orange SIGMA-ALDRICH −20°C DMSO: 2 mg/mL, clear powder ≥95% (HPLC)
Click Add to Quote for price and delivery
-
+