AMTB hydrate, >=98% (HPLC)

AMTB hydrate, >=98% (HPLC)

Application

AMTB hydrate has been used as an inhibitor of transient receptor potential cation channel, subfamily melastatin, member 8 (TRPM8) in breast cancer cells and murine T cells.

Biochem/physiol Actions

AMTB is a 2-benzyloxy-benzoic acid amide derivative, which also inhibits voltage-gated sodium channels (Nav) and their isoforms.

AMTB is a TRPM8-selective antagonist with no cross reactivity to TRPV1 or 4. The pIC50 of icilin activation of TRPM8 is 6.23 i.v. administration of AMTB reduced the frequency of rhythmic contractions in volume-loaded bladder and inhibited blood pressure and visceromotor reflex responses to bladder distention.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level InChI key InChI Manufacturer Solubility Form Assay Price Quantity
3574020 AMTB hydrate, >=98% (HPLC) white to tan 100 RTYVTAQFASBIDN-UHFFFAOYSA-N 1S/C23H26N2O2S.ClH.H2O/c1-18-8-2-3-9-19(18)17-27-22-12-5-4-11-21(22)23(26)25(14-7-13-24)16-20-10-6-15-28-20;;/h2-6,8-12,15H,7,13-14,16-17,24H2,1H3;1H;1H2 SIGMA-ALDRICH DMSO: ≥10 mg/mL powder ≥98% (HPLC)
£487.50 (exc VAT) per 25MG
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3574021 AMTB hydrate, >=98% (HPLC) white to tan 100 RTYVTAQFASBIDN-UHFFFAOYSA-N 1S/C23H26N2O2S.ClH.H2O/c1-18-8-2-3-9-19(18)17-27-22-12-5-4-11-21(22)23(26)25(14-7-13-24)16-20-10-6-15-28-20;;/h2-6,8-12,15H,7,13-14,16-17,24H2,1H3;1H;1H2 SIGMA-ALDRICH DMSO: ≥10 mg/mL powder ≥98% (HPLC)
£168.54 (exc VAT) per 5MG
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