APRATASTAT

APRATASTAT

Biochem/physiol Actions

Apratastat (TMI-005) is an orally active, potent and selective dual inhibitor of disintegrin metalloenzyme 17 (ADAM17/ TACE) and matrix metalloprotease (MMP).

General description

Apratastat is one of the thiomorpholine sulfonamide hydroxymate selective inhibitors of ADAM17 (a disintegrin and metalloproteinase).

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level InChI key InChI Manufacturer Solubility Form Assay Price
3575058 APRATASTAT white to beige 100 MAVDNGWEBZTACC-HNNXBMFYSA-N 1S/C17H22N2O6S2/c1-17(2)15(16(21)18-22)19(9-12-26-17)27(23,24)14-7-5-13(6-8-14)25-11-4-3-10-20/h5-8,15,20,22H,9-12H2,1-2H3,(H,18,21)/t15-/m0/s1 SIGMA-ALDRICH DMSO: 20 mg/mL, clear powder ≥98% (HPLC)
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3575059 APRATASTAT white to beige 100 MAVDNGWEBZTACC-HNNXBMFYSA-N 1S/C17H22N2O6S2/c1-17(2)15(16(21)18-22)19(9-12-26-17)27(23,24)14-7-5-13(6-8-14)25-11-4-3-10-20/h5-8,15,20,22H,9-12H2,1-2H3,(H,18,21)/t15-/m0/s1 SIGMA-ALDRICH DMSO: 20 mg/mL, clear powder ≥98% (HPLC)
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