TC-2153

Biochem/physiol Actions

TC-2153 is a potent inhibitor of STEP (STriatal-Enriched protein tyrosine Phosphatase) that forms a reversible covalent bond with the catalytic cysteine in STEP. TC-2153 increases tyrosine phosphorylation of STEP substrates ERK1/2, Pyk2, and GluN2B in cell cultures. TC-2153 improves cognitive function in transgenic AD mice.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Assay Price
3574721 TC-2153 white to beige 100 SIGMA-ALDRICH −20°C DMSO: 5 mg/mL, clear powder ≥95% (HPLC)
3574722 TC-2153 white to beige 100 SIGMA-ALDRICH −20°C DMSO: 5 mg/mL, clear powder ≥95% (HPLC)
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