CILENGITIDE TRIFLUOROACETIC ACID SALT

CILENGITIDE TRIFLUOROACETIC ACID SALT

Stock Code: 3575128
Manufacturer Part No: SML1594-25MG
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£785.57 (exc VAT) per 25MG
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Application


Cilengitide trifluoroacetic acid salt has been used as an inhibitor of integrin ?v?5.


Biochem/physiol Actions


It exhibits antitumor activity in glioblastoma multiforme tumors. Integrins are heterodimers of ? and ? chain. They are transmembrane receptors which are responsible for cell-to-cell and cell-extracellular matrix interactions. They control tumor angiogenesis, invasion and migration.


Cilengitide is a vascular targeting agent (VTA) that acts as an integrin antagonist. Cilengitide is a cyclized Arg-Gly-Glu(RGD)-containing pentapeptide that selectively blocks activation of the Avβ3 and Avβ5 integrins.


Packaging


5, 25 mg in glass bottle

Colourwhite to beige
Quality Level100
ManufacturerSIGMA-ALDRICH
Storage Temp.−20°C
SolubilityH2O: 20 mg/mL, clear
Formpowder
Assay≥98% (HPLC)

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