CILENGITIDE TRIFLUOROACETIC ACID SALT
Application
Cilengitide trifluoroacetic acid salt has been used as an inhibitor of integrin ?v?5.
Biochem/physiol Actions
It exhibits antitumor activity in glioblastoma multiforme tumors. Integrins are heterodimers of ? and ? chain. They are transmembrane receptors which are responsible for cell-to-cell and cell-extracellular matrix interactions. They control tumor angiogenesis, invasion and migration.
Cilengitide is a vascular targeting agent (VTA) that acts as an integrin antagonist. Cilengitide is a cyclized Arg-Gly-Glu(RGD)-containing pentapeptide that selectively blocks activation of the Avβ3 and Avβ5 integrins.
Packaging
5, 25 mg in glass bottle
| Colour | white to beige |
|---|---|
| Quality Level | 100 |
| Manufacturer | SIGMA-ALDRICH |
| Storage Temp. | −20°C |
| Solubility | H2O: 20 mg/mL, clear |
| Form | powder |
| Assay | ≥98% (HPLC) |
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