6-THIO-2-DEOXYGUANOSINE

Descriptions

Application

6-Thio-2?-Deoxyguanosine has been used in secreted luciferase enzyme activity in tonsillar cancer cells.

Biochem/physiol Actions

6-Thio-2′-deoxyguanosine (6-thio-dG) is a nucleoside analog and telomerase substrate that is incorporated into de novo–synthesized telomeres. 6-Thio-2′-deoxyguanosine induces telomere dysfunction and rapid cell death in cancer cells, while spearing telomerase-negative cells.

Packaging

5, 25 mg in glass bottle

Specifications

Colour	white to brown
Quality Level	100
InChI key	SCVJRXQHFJXZFZ-HSUXUTPPSA-N
InChI	1S/C10H13N5O3S/c11-10-13-8-7(9(19)14-10)12-3-15(8)6-1-4(17)5(2-16)18-6/h3-6,16-17H,1-2H2,(H3,11,13,14,19)/t4-,5-,6-/m1/s1
Manufacturer	SIGMA-ALDRICH
Solubility	DMSO: 5 mg/mL, clear (warmed)
Form	powder
Assay	≥97% (HPLC)