ZIBOTENTAN

ZIBOTENTAN

Stock Code: 3575070
Manufacturer Part No: SML1550-25MG
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Biochem/physiol Actions


Zibotentan is a potent and selective endothelin ET(A) receptor antagonist with an IC50 of 21 nM for the ETA receptor subtype and no binding observed even at 10,000 nM for ETB.


Zibotentan has been found to inhibit cell proliferation, invasion and metastasis in cancer models. In clinical trials on patients with castration-resistant prostate cancer and bone metastasis, who were pain-free or had mild pain, zibotentan treatment resulted in better overall survival as compared to placebo.


General description


Zibotentan is an orally bioavailable, non-peptide ETA (endothelin) receptor-specific antagonist, with no activity against ETB receptor.


Packaging


5, 25 mg in glass bottle

Colourwhite to beige
Quality Level100
InChI keyFJHHZXWJVIEFGJ-UHFFFAOYSA-N
InChI1S/C19H16N6O4S/c1-12-10-21-17(19(23-12)28-2)25-30(26,27)15-4-3-9-20-16(15)13-5-7-14(8-6-13)18-24-22-11-29-18/h3-11H,1-2H3,(H,21,25)
ManufacturerSIGMA-ALDRICH
Formpowder
Assay≥98% (HPLC)

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