YM-26734

YM-26734

Stock Code: 3574623
Manufacturer Part No: SML1226-5MG
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£168.54 (exc VAT) per 5MG
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Biochem/physiol Actions


YM-26734 is a competitive inhibitor of the secreted (Group II) form of phospholipase A2. The IC50 against rabbit platelet derived sPLA2 is 85 nM. YM-26734 is active against, but less potent for group I (pancreatic) sPLA2 (porcine pancreatic enzyme IC50 = 7 µM), and does not inhibit intracellular PLA2 isoforms.


YM-26734 is a natural product analog and a derivative of YM-26567-1, which is found in the fruit ofHorsfieldia amygdaline. It exhibits a broad inhibitory spectrum towards different sPLA2s.


Packaging


5, 25 mg in glass bottle

Colourwhite to beige
Quality Level100
InChI keyCEJAYJCUSZHYDS-UHFFFAOYSA-N
InChI1S/C45H62O8/c1-3-5-7-9-11-13-15-17-19-21-36(48)41-43(50)40(44(51)42(45(41)52)37(49)22-20-18-16-14-12-10-8-6-4-2)35-30-38(31-23-25-32(46)26-24-31)53-39-29-33(47
ManufacturerSIGMA-ALDRICH
SolubilityDMSO: 20 mg/mL, clear
Formpowder
Assay≥95% (HPLC)

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