UNC3866 TRIFLUOROACETATE SALT

UNC3866 TRIFLUOROACETATE SALT

Stock Code: 3576273
Manufacturer Part No: SML2408-25MG
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£630.96 (exc VAT) per 25MG
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Biochem/physiol Actions


UNC3866 inhibits the CBX chromodomains of the Polycomb repressive complex 1 (PRC1), which is involved in transcriptional repression. UNC3866 selectively targets CBX4 and CBX7 most potently, with Kd values of ~100 nM. The PRC1 chromodomains facilitate PRC1-mediated transcriptional repression by targeting the complex to Trimethyllysine 27 on histone 3 (H3K27me3). UNC3866 antagonizes the methyllysine (Kme) reading function, and has been shown to inhibit the PC3 prostate cancer cell proliferation associated with CBX7 overexpression.


Antagonist of chromodomains CBX4/7 of Polycomb repressive complex 1

Colourwhite to off-white
ManufacturerSIGMA-ALDRICH
Storage Temp.−20°C
Formlyophilized powder (white)
Assay≥98% (HPLC)

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