TREPROSTINIL
Biochem/physiol Actions
Treprostinil is a stable synthetic analog of prostacyclin (prostaglandin PGI2), an IP receptor agonist used clinically for the treatment of pulmonary arterial hypertension. It is a potent vasodilator with antithrombotic, antiproliferative and anti-inflammatory properties.
Treprostinil elicits a longer half-life when compared with iloprost. It mediates inhibition of transforming growth factor-? (TGF-?) and nuclear factor-?B (NF-?B) signaling pathways. Treprostinil effectively reduces right ventricular systolic pressure and inhibits the recruitment of circulating fibrocyte.
| Colour | white to beige |
|---|---|
| Quality Level | 100 |
| InChI key | IQKAWAUTOKVMLE-DQHZMXPSSA-M |
| InChI | 1S/C23H34O5.Na/c1-2-3-4-7-17(24)9-10-18-19-11-15-6-5-8-22(28-14-23(26)27)20(15)12-16(19)13-21(18)25;/h5-6,8,16-19,21,24-25H,2-4,7,9-14H2,1H3,(H,26,27);/q;+1/p- |
| Manufacturer | SIGMA-ALDRICH |
| Form | powder |
| Assay | ≥98% (HPLC) |
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