TPCA-1, >=95% (HPLC), powder

TPCA-1, >=95% (HPLC), powder

Stock Code: 3576970
Manufacturer Part No: T1452-5MG
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£852.43 (exc VAT) per 5MG
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Application


TPCA-1 has been used to study its cytotoxic effects in RPMI8226 and LP1 cell lines. It has also been used as a culture media supplement for nuclear protein fractions extracted from human airway smooth muscle cells.


Biochem/physiol Actions


TPCA-1 is a potent and selective inhibitor of human IκB kinase-2 (IKK-2) with IC50 = 17.9 nM for IKK-2 compared to 400nm for IKK-1. It has been used to study inhibition of IKK-2 to prevent inflammatory mediator release in animal models of arthritis and airway inflammation.


Features and Benefits


This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.


Packaging


1, 5 mg in glass bottle


Preparation Note


TPCA-1 is soluble in DMSO at a concentration that is greater than or equal to 10 mg/ml. It is insoluble in water.

Colourwhite to light brown
Quality Level100
InChI keySAYGKHKXGCPTLX-UHFFFAOYSA-N
InChI1S/C12H10FN3O2S/c13-7-3-1-6(2-4-7)9-5-8(10(14)17)11(19-9)16-12(15)18/h1-5H,(H2,14,17)(H3,15,16,18)
ManufacturerSIGMA-ALDRICH
Formpowder
Assay≥95% (HPLC)

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