Tocainide hydrochloride, >=98% (HPLC), solid

Tocainide hydrochloride, >=98% (HPLC), solid

Stock Code: 3576963
Manufacturer Part No: T0202-10MG
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Application


Tocainide hydrochloride may be used in cell signaling studies.


Biochem/physiol Actions


Tocainide hydrochloride is a primary amine analog of lidocaine (lignocaine), used for the treatment of tinnitus. It blocks the sodium channels in the pain-producing foci in the nerve membranes and renders an analgesic effect in trigeminal neuralgia.


Tocainide hydrochloride is a sodium channel blocker; Class IB antiarrhythmic.


Features and Benefits


This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.


Tocainide is voltage-dependent and use-dependent sodium channel blocker (class IB type antiarrhythmic); Ki = 115 µM in blockade of inactivated-state sodium channels; IC50 = 985µM in blockade of Na+ currents at a holding potential (HP) of -140 mV; IC50 = 254 µM in blockade of Na+ currents at HP -70 mV; IC50 = 523 µM in blockade of Na+ currents at tonic block (-100 mV); IC50 = 248 µM for use-dependent block at 10 Hz.


Packaging


10, 50 mg in glass bottle

Colourwhite
Quality Level100
InChI keyAMZACPWEJDQXGW-UHFFFAOYSA-N
InChI1S/C11H16N2O.ClH/c1-7-5-4-6-8(2)10(7)13-11(14)9(3)12;/h4-6,9H,12H2,1-3H3,(H,13,14);1H
ManufacturerSIGMA-ALDRICH
Formsolid
Assay≥98% (HPLC)

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