TIOTROPIUM BROMIDE HYDRATE
Application
Tiotropium bromide monohydrate may be used as a long-acting muscarinic receptor antagonist (LAMA) in a comparative study to explore its efficacy in the downregulation of the cough reflex in rabbits.
Biochem/physiol Actions
Tiotropium bromide exhibits more beneficial effects on pulmonary function than other anticholinergic and ?-2 adrenergic agents. Tiotropium can prevent the proliferation of fibroblasts and myofibroblasts induced by acetylcholine. It can block human monocyte chemotaxis.
Tiotropium Bromide is an anticholinergic bronchodilator. It is considered a long-acting muscarinic receptor antagonist (LAMA) and is used clinically as an inhaled bronchodilator for chronic obstructive pulmonary disease (COPD) and asthma.
| Colour | white to beige |
|---|---|
| InChI key | MQLXPRBEAHBZTK-YQMLGFMRSA-M |
| InChI | 1S/C19H22NO4S2.BrH.H2O/c1-20(2)12-9-11(10-13(20)17-16(12)24-17)23-18(21)19(22,14-5-3-7-25-14)15-6-4-8-26-15;;/h3-8,11-13,16-17,22H,9-10H2,1-2H3;1H;1H2/q+1;;/p- |
| Manufacturer | SIGMA-ALDRICH |
| Storage Temp. | 2-8°C |
| Solubility | H2O: 2 mg/mL, clear |
| Form | powder |
| Assay | ≥98% (HPLC) |
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