Tigecycline hydrate, >=98% (HPLC)

Tigecycline hydrate, >=98% (HPLC)

Stock Code: 3573552
Manufacturer Part No: PZ0021-5MG
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Application


TIGECYCLINE HYDRATE has been used:for antibiotic susceptibility testingto study its effects on multiple nonsmall cell lung cancer (NSCLC) cell linesto evaluate its effects on the binding of fluoroquinolones to human serum albuminas a standard to investigate the penetration of tigecycline into cornea, aqueous humor and vitreous humor


Biochem/physiol Actions


Tigecycline is a broad spectrum glycylcycline antibiotic. Tigecycline is bacteriostatic, that inhibits protein synthesis by binding to the 30S ribosomal subunit of bacteria and thereby blocking entry of Aminoacyl-tRNA into the A site of the ribosome during prokaryotic translation. Tigecycline is active against resistant strains of gram-positive and gram-negative bacteria, avoiding the two most common mechanisms of resistance to the tetracycline antimicrobials: tetracycline efflux pump proteins and ribosomal protection proteins.


General description


Tigecycline is used to treat complicated skin and skin structure infections (cSSSI) and complicated intraabdominal infections.


Legal Information


Pfizer is a registered trademark of Pfizer, Inc.


Sold for research purposes under agreement from Pfizer Inc.


Other Notes


This compound was developed by Pfizer for Immunology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.


air sensitive


Packaging


5, 25 mg in glass bottle

Colouroff-white to yellow-brown
InChI keyPMPLAEFBZIFHAR-KXLOKULZSA-N
InChI1S/C29H39N5O8.H2O/c1-28(2,3)31-11-17(35)32-15-10-16(33(4)5)13-8-12-9-14-21(34(6)7)24(38)20(27(30)41)26(40)29(14,42)25(39)18(12)23(37)19(13)22(15)36;/h10,12,14,
ManufacturerSIGMA-ALDRICH
Formpowder
Assay≥98% (HPLC)

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