TFLLR-NH2 trifluoroacetate salt, , >98% (HPLC)

TFLLR-NH2 trifluoroacetate salt, , >98% (HPLC)

Stock Code: 3576979
Manufacturer Part No: T7830-5MG
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£206.14 (exc VAT) per 5MG
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Amino Acid Sequence


Thr-Phe-Leu-Leu-Arg-NH2


Application


TFLLR-NH2 trifluoroacetate salt has been used as a protease-activated receptor-1 (PAR-1) agonist to study its effects on hippocampal CA1 pyramidal neurons and Swell1 knock out mice (cKO).


Biochem/physiol Actions


TFLLR-NH2 is a protease-activated receptor (PARs) agonist which is more selective to PAR-1 than SFLLRN-NH2. Protease-activated receptors (PARs) are present on various organs including, plateles, mast cell, gallblader, oesophagus etc, and regulate various physiological processes including human platelet aggregation, vascular contraction/relaxation, and an increase in endothelial permeability. Recent papers indicated that PAR′s are also involved in sensory processing. Specificly PAR ligands enhance glutamatergic excitatory transmission in substantia gelatinosa (SG) neurons of adult rat spinal cord slices.


Packaging


5, 25 mg in glass bottle


Preparation Note


TFLLR-NH2 trifluoroacetate is soluble in water at a concentration that is greater than 2 mg/ml.

Colourwhite to tan
Quality Level100
InChI keyQVNWOGSDGQDGHP-MKVNCOEFSA-N
InChI1S/C31H53N9O6.C2HF3O2/c1-17(2)14-22(27(43)37-21(26(33)42)12-9-13-36-31(34)35)38-28(44)23(15-18(3)4)39-29(45)24(16-20-10-7-6-8-11-20)40-30(46)25(32)19(5)41;3-2(
ManufacturerSIGMA-ALDRICH
SolubilityH2O: >2 mg/mL
Formlyophilized powder
Assay>98% (HPLC)

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