Sumo-1/sentrin-1 (gst-tagged)

Sumo-1/sentrin-1 (gst-tagged)

Stock Code: 3573884
Manufacturer Part No: S0439-500UG
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Application


SUMO-1 human has been used in pre-absorption for negative immunostaining to confirm the specificity of the small ubiquitin like modifier 1 (SUMO-1) antibody.


Biochem/physiol Actions


Small ubiquitin-like modifier 1 (SUMO-1) plays a key role in modulating survival, migration, and signal transduction in some cell lines. It can prevent in vitro migration and invasion of RA fibroblast-like synoviocytes (FLSs). Higher expression of SUMO-1 may result in joint destruction in rheumatoid arthritis (RA).


Conjugated to a variety of proteins by UbcH9, including RanGAP1, IκBα, and PML without the requirement of an equivalent E3 ubiquitin ligase.


General description


Small ubiquitin-like modifier 1 (SUMO-1), a protein, is one of the 5 SUMO paralogs expressed in mammalian cells with a low but significant homology with ubiquitin. This SUMO-1-GST fusion protein is produced from a DNA sequence corresponding to human SUMO-1 fused to a glutathione S-transferase (GST)-tag and is expressed in E. coli cells.


Physical form


Solution in 50 mM HEPES, pH 8.0, 150 mM NaCl and 1 mM DTT.

Quality Level200
ManufacturerSIGMA-ALDRICH
Storage Temp.−70°C
Assay≥95% (SDS-PAGE)

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