Sumanirole maleate has been used as a dopamine type 2 receptor (D2R) agonist to study its effects on spatial learning and memory in rats.
Biochem/physiol Actions
Sumanirole is a highly selective and potent dopamine D2 receptor agonist that decreased plasma prolactin levels and depressed dopamine neuron firing rates in the substantia nigra pars compacta. Sumanirole potently stimulates locomotor activity in in animal models of Parkinson’;s disease.
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