SR8278, >=98%, semisolid

SR8278, >=98%, semisolid

Stock Code: 3573938
Manufacturer Part No: S9576-5MG
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Application


SR8278 was used as rev-erb alpha antagonist to study the regulation of glucagon secretion in mouse pancreatic alpha cells1 and beta cells.2


SR8278 has been used as a nuclear receptor subfamily 1, group D, member 1 (NR1D1) antagonist to study its effects on starvation-induced macrophages.


Biochem/physiol Actions


SR8278 is a Nuclear Heme Receptor REV-ERB antagonist. REV-ERBα plays a critical role in regulation of the circadian rhythm by repressing target gene activities. Additionally, REV-ERBα has been shown to regulate metabolic processes including lipid and glucose metabolism. SR8278 blocks the ability of the synthetic agonist GSK4112 to enhance REV-ERBα-dependent repression and stimulates the expression of REV-ERBα target genes involved in gluconeogenesis.


Packaging


5, 25 mg in glass bottle

Colourwhite
Quality Level100
InChI keyUIEBLUZPSFAFOC-UHFFFAOYSA-N
InChI1S/C18H19NO3S2/c1-3-22-18(21)14-10-12-6-4-5-7-13(12)11-19(14)17(20)15-8-9-16(23-2)24-15/h4-9,14H,3,10-11H2,1-2H3
ManufacturerSIGMA-ALDRICH
SolubilityDMSO: ≥30 mg/mL
Formlyophilized powder
Assay≥98% (HPLC)

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