SR 12813, >=98%, solid

SR 12813, >=98%, solid

Stock Code: 3573905
Manufacturer Part No: S4194-1MG
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£60.87 (exc VAT) per 1MG
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Application


SR-12813 was used as control in pregnane X receptor (PXR) binding assay performed in HepG2 liver carcinoma cells and PXR-activation assay mediated by dehydroepiandrosterone in human hepatocytes.


Biochem/physiol Actions


SR 12813 is a pregnane X receptor (PXR, NR 112) agonist; cholesterol lowering drug; HMGCoA reductase inhibitor.


SR-12813 is a 1,1-bisphosphonate ester that exhibits hypocholesterolemic activity. It decreases the biosynthesis of cholesterol by enhancing the degradation of HMG-CoA reductase.


Features and Benefits


This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.


This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.


Packaging


1, 5 mg in glass bottle

Quality Level100
InChI keyYQLJDECYQDRSBI-UHFFFAOYSA-N
InChI1S/C24H42O7P2/c1-11-28-32(26,29-12-2)21(33(27,30-13-3)31-14-4)17-18-15-19(23(5,6)7)22(25)20(16-18)24(8,9)10/h15-17,25H,11-14H2,1-10H3
ManufacturerSIGMA-ALDRICH
Formsolid
Assay≥98%

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