SCH-28080, >=98% (HPLC), solid

SCH-28080, >=98% (HPLC), solid

Stock Code: 3573907
Manufacturer Part No: S4443-10MG
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£257.68 (exc VAT) per 10MG
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Application


SCH-28080 was used to treat zebrafish embryos to study the role of H+/K+-ATPase in establishment of left-right axis during development.


Biochem/physiol Actions


SCH-28080 is a potent inhibitor of gastric H+ and K+-ATPase. The novel antiulcer agents, SCH-28080 and SCH-32651 were examined for their ability to inhibit the H+K+ ATPase enzyme activity in a preparation of microsomal membranes from rabbit fundic mucosa. SCH- 28080 inhibited the isolated enzyme activity with a potency similar to omeprazole, IC50s of 2.5 and 4.0 µM respectively. SCH 32651 was less potent exhibiting an IC50 of 200.0 µM. Both compounds may therefore exert their antisecretory activity via a direct inhibition of the parietal cell H+K+ ATPase.


Packaging


10, 50 mg in glass bottle

Colourwhite to light tan
Quality Level100
InChI keyPYKJFEPAUKAXNN-UHFFFAOYSA-N
InChI1S/C17H15N3O/c1-13-15(9-10-18)20-11-5-8-16(17(20)19-13)21-12-14-6-3-2-4-7-14/h2-8,11H,9,12H2,1H3
ManufacturerSIGMA-ALDRICH
Compatibilityfor use with ABI 7700
Formsolid
Assay≥98% (HPLC)

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