Rosiglitazone, (HPLC), >=98% (HPLC)

Rosiglitazone, (HPLC), >=98% (HPLC)

Stock Code: 3573876
Manufacturer Part No: R2408-50MG
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£454.07 (exc VAT) per 50MG
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Application


Rosiglitazone has been used:as a medium constituent for adipocyte differentiationin the cell proliferation assay in human colonic carcinoma cell linesfor Bcl-2-like protein 13 (Bcl2l13) expression in adipocytesas a peroxisome proliferator-activated receptor gamma (PPAR?) ligand


Biochem/physiol Actions


Rosiglitazone is a potent agonist for PPARγ with an EC50 of 43 nM for the human receptor. It is antidiabetic, working as an insulin sensitizer by binding to the PPARγ receptors in fat cells and making the cells more responsive to insulin.


Features and Benefits


This compound is a featured product for ADME Tox and Gene Regulation research. Discover more featured ADME Tox and Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.


This compound is featured on the AMPKs and Nuclear Receptors (PPARs) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.


This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.


Packaging


10, 50 mg in glass bottle

Quality Level100
InChI keyYASAKCUCGLMORW-UHFFFAOYSA-N
InChI1S/C18H19N3O3S/c1-21(16-4-2-3-9-19-16)10-11-24-14-7-5-13(6-8-14)12-15-17(22)20-18(23)25-15/h2-9,15H,10-12H2,1H3,(H,20,22,23)
ManufacturerSIGMA-ALDRICH
Formpowder
Assay≥98% (HPLC)

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