PX 12, >=98% (HPLC), powder
Application
PX 12 has been used as a thioredoxin 1 inhibitor prostate cancer cell lines to analyse its effect on cell viability. It has also been used as a hypoxia-inducible factor (HIF)-1? inhibitor to treat H2228 cells.
Biochem/physiol Actions
PX-12 inhibits the thioredoxin redox system and HIF-1a activity. PX 12 inhibits hypoxia-induced HIF-1a transcriptional activity (IC50 11 nM) and proliferation of HT29 and MCF-7 tumor cells (IC50 1.9 and 0.9 uM, respectively).
Packaging
5, 25 mg in glass bottle
| Colour | off-white to tan |
|---|---|
| Quality Level | 100 |
| InChI key | BPBPYQWMFCTCNG-UHFFFAOYSA-N |
| InChI | 1S/C7H12N2S2/c1-3-6(2)10-11-7-8-4-5-9-7/h4-6H,3H2,1-2H3,(H,8,9) |
| Manufacturer | SIGMA-ALDRICH |
| Solubility | DMSO: >25 mg/mL |
| Form | powder |
| Assay | ≥98% (HPLC) |
There are no downloads for this product.
