PX 12, >=98% (HPLC), powder

PX 12, >=98% (HPLC), powder

Stock Code: 3573465
Manufacturer Part No: M5324-25MG
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£578.04 (exc VAT) per 25MG
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Application


PX 12 has been used as a thioredoxin 1 inhibitor prostate cancer cell lines to analyse its effect on cell viability. It has also been used as a hypoxia-inducible factor (HIF)-1? inhibitor to treat H2228 cells.


Biochem/physiol Actions


PX-12 inhibits the thioredoxin redox system and HIF-1a activity. PX 12 inhibits hypoxia-induced HIF-1a transcriptional activity (IC50 11 nM) and proliferation of HT29 and MCF-7 tumor cells (IC50 1.9 and 0.9 uM, respectively).


Packaging


5, 25 mg in glass bottle

Colouroff-white to tan
Quality Level100
InChI keyBPBPYQWMFCTCNG-UHFFFAOYSA-N
InChI1S/C7H12N2S2/c1-3-6(2)10-11-7-8-4-5-9-7/h4-6H,3H2,1-2H3,(H,8,9)
ManufacturerSIGMA-ALDRICH
SolubilityDMSO: >25 mg/mL
Formpowder
Assay≥98% (HPLC)

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