PR-619, >=95% (HPLC)
Application
PR-619 has been used:as a component of lysis buffer and also as a deubiquitinase inhibitor to treat proteins derived from SILAC-labeled Jurkat cellsas a pan-deubiquitinase inhibitor to study its effect on adenoassociated virus (AAV) transductionin radioimmunoprecipitation assay buffer (RIPA) buffer used for ubiquitination assays
Biochem/physiol Actions
PR-619 is a cell permeable broad spectrum deubiquitylating enzymes (DBUs) inhibitor. PR-619 induces the accumulation of polyubiquitylated proteins in cells without directly affecting proteasome activity.
Packaging
1, 5 mg in glass bottle
| Colour | white to beige |
|---|---|
| Quality Level | 100 |
| InChI key | ZXOBLNBVNROVLC-UHFFFAOYSA-N |
| InChI | 1S/C7H5N5S2/c8-2-13-4-1-5(14-3-9)7(11)12-6(4)10/h1H,(H4,10,11,12) |
| Manufacturer | SIGMA-ALDRICH |
| Solubility | DMSO: 5 mg/mL (clear solution) |
| Form | powder |
| Assay | ≥95% (HPLC) |
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