POSACONAZOLE

POSACONAZOLE

Stock Code: 3576091
Manufacturer Part No: SML2287-25MG
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£695.04 (exc VAT) per 25MG
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Application


Posaconazole has been used:in antifungal susceptibility testing of Aspergillus terreusas a lanosterol14?-demethylase (CYP51)-specific inhibitor to study its effects on membrane permeability in Candida albicans cellsto study its effects on promastigotes


Biochem/physiol Actions


Posaconazole is a highly potent broadspectrum antifungal agent against the yeast infection caused especially by Candida sp. It blocks the growth of fungi by inhibiting the enzymelanosterol14?-demethylase (CYP51). In contrast to other antifungal azoles, posaconazole has been reported not to induce the efflux pump mechanism. Posaconazole exhibits antichagasic effects against different strains of Trypanosoma cruzi causing Chagas disease.

Colourwhite to beige
InChI keyRAGOYPUPXAKGKH-XAKZXMRKSA-N
InChI1S/C37H42F2N8O4/c1-3-35(26(2)48)47-36(49)46(25-42-47)31-7-5-29(6-8-31)43-14-16-44(17-15-43)30-9-11-32(12-10-30)50-20-27-19-37(51-21-27,22-45-24-40-23-41-45)33-
ManufacturerSIGMA-ALDRICH
Storage Temp.−20°C
SolubilityDMSO: 2 mg/mL, clear
Formpowder
Assay≥98% (HPLC)

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