Pomalidomide, >=98% (HPLC)

Pomalidomide, >=98% (HPLC)

Stock Code: 3573514
Manufacturer Part No: P0018-5MG
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£190.82 (exc VAT) per 5MG
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Application


Pomalidomide has been used:to treat BV173 cells to study the role of proteolysis targeting chimera (PROTAC) compound, JQ1-CRBN, in inducing specific class-I major histocompatibility complex (MHC-I) peptidesfor apoptosis studies and intracellular calcium analysisas a fetal hemoglobin (HbF) agent to study the additive effect with UNC0638 on the levels of fetal hemoglobin expression in β;-thalassemia/ variant hemoglobin E (HbE) erythroid progenitor cells


Biochem/physiol Actions


Pomalidomide is a second generation immunomodulator, TNF-α inhibitor, and thalidomide analog.


Pomalidomide is an effective fetal hemoglobin (HbF) inducer that downregulates the key γ-globin repressors, SRY-box transcription factor 6 (SOX6), and BAF chromatin remodeling complex subunit (BCL11A).


Features and Benefits


This compound is featured on the Cytokine Receptors (Tumor Necrosis Receptor Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.


Packaging


5, 25 mg in glass bottle

Colouryellow
Quality Level100
InChI keyUVSMNLNDYGZFPF-UHFFFAOYSA-N
InChI1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)
ManufacturerSIGMA-ALDRICH
Formpowder
Assay≥98% (HPLC)

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