Pifithrin-mu, >=97% (HPLC), solid
Application
Pifithrin-? has been used:to treat microglial cell line to analyse its neuroprotective effect on M1-like and M2-like phenotypeas heat shock protein (HSP)-70 inhibitor, to treat transfected Marc-145 cellsto inhibit heat shock cognate 70 (Hsc70) to elucidate heat shock chaperones mouse embryonic stem cells
Biochem/physiol Actions
Pifithrin-µ is an inhibitor of p53 binding and anti-apoptotic, which directly inhibits p53 binding to mitochondria as well as to Bcl-xL and Bcl-2 proteins. PFTµ rescues cells from lethal γ-irradiation-induced cell death. Because pifithrin-µ shuts down only the p53-mitochondrial pathway without affecting the transcriptional functions of p53, it is superior to pifithrin-α.
Pifithrin-?(PFT-?) has neuroprotective capabilities against cell death in a preclinical model of hypoxia-ischemia (HI)-induced neonatal encephalopathy. It inhibits nuclear factor-?B (NF-?B) pathway by inhibiting the interaction of molecular chaperone heat shock protein (HSP)-70 with its substrates.
Packaging
5, 10 mg in glass bottle
| Quality Level | 100 |
|---|---|
| InChI key | ZZUZYEMRHCMVTB-UHFFFAOYSA-N |
| InChI | 1S/C8H7NO2S/c9-12(10,11)7-6-8-4-2-1-3-5-8/h1-5H,(H2,9,10,11) |
| Manufacturer | SIGMA-ALDRICH |
| Solubility | DMSO: soluble >10 mg/mL, clear, H2O: insoluble |
| Form | solid |
| Assay | ≥97% (HPLC) |
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