Pifithrin-mu, >=97% (HPLC), solid

Pifithrin-mu, >=97% (HPLC), solid

Stock Code: 3573520
Manufacturer Part No: P0122-10MG
Order Now for 21 day delivery
£242.36 (exc VAT) per 10MG
Quantity: - +

Application


Pifithrin-? has been used:to treat microglial cell line to analyse its neuroprotective effect on M1-like and M2-like phenotypeas heat shock protein (HSP)-70 inhibitor, to treat transfected Marc-145 cellsto inhibit heat shock cognate 70 (Hsc70) to elucidate heat shock chaperones mouse embryonic stem cells


Biochem/physiol Actions


Pifithrin-µ is an inhibitor of p53 binding and anti-apoptotic, which directly inhibits p53 binding to mitochondria as well as to Bcl-xL and Bcl-2 proteins. PFTµ rescues cells from lethal γ-irradiation-induced cell death. Because pifithrin-µ shuts down only the p53-mitochondrial pathway without affecting the transcriptional functions of p53, it is superior to pifithrin-α.


Pifithrin-?(PFT-?) has neuroprotective capabilities against cell death in a preclinical model of hypoxia-ischemia (HI)-induced neonatal encephalopathy. It inhibits nuclear factor-?B (NF-?B) pathway by inhibiting the interaction of molecular chaperone heat shock protein (HSP)-70 with its substrates.


Packaging


5, 10 mg in glass bottle

Quality Level100
InChI keyZZUZYEMRHCMVTB-UHFFFAOYSA-N
InChI1S/C8H7NO2S/c9-12(10,11)7-6-8-4-2-1-3-5-8/h1-5H,(H2,9,10,11)
ManufacturerSIGMA-ALDRICH
SolubilityDMSO: soluble >10 mg/mL, clear, H2O: insoluble
Formsolid
Assay≥97% (HPLC)

There are no downloads for this product.