PF-2545920 HYDROCHLORIDE

PF-2545920 HYDROCHLORIDE

Stock Code: 3573803
Manufacturer Part No: PZ0351-5MG
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Biochem/physiol Actions


PF-2545920 hydrochloride (MP-10) is a potent and selective cyclic nucleotide phosphodiesterase (PDE) 10A competitive inhibitor with a reported IC50 value of 1.26 nM. PDE10A hydrolyzes both cAMP and cGMP, and is highly expressed in medium spiny neurons of the mammalian striatum and in basal ganglia areas where D1 and D2 dopamine receptors are expressed. PF-2545920 has been studied for treatment of schizophrenia and Huntington′s disease.


Legal Information


Pfizer is a registered trademark of Pfizer, Inc.


Sold for research purposes under agreement from Pfizer Inc.


Packaging


5, 25 mg in glass bottle

Colourwhite to brown
Quality Level100
ManufacturerSIGMA-ALDRICH
SolubilityDMSO: 20 mg/mL, clear
Formpowder
Assay≥97% (HPLC)

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