PF-06807656
Biochem/physiol Actions
PF-06807656 is a 3-sulfamoylbenzamide-based renal outer medullary potassium channel (ROMK, CCNJ1, Kir1.1) inhibitor (IC50 = 61 nM by whole cell patch clamp) that is insensitive to K80M or N171D pore mutation and exhibits high selectivity for human over rat species (IC50 against thallium sulfate/TlSO4-stimulated influx = 391 nM vs. >30 μM using human or rat ROMK1-expressing HEK293 cells; 82% vs. 0% inhibition by patch clamp using human or rat ROMK2-expressing HEK293 cells).
Legal Information
Sold for research purposes under agreement from Pfizer Inc.
| Colour | white to beige |
|---|---|
| Quality Level | 100 |
| Manufacturer | SIGMA-ALDRICH |
| Storage Temp. | 2-8°C |
| Solubility | DMSO: 2 mg/mL, clear |
| Form | powder |
| Assay | ≥98% (HPLC) |
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