PEMETREXED DISODIUM HEPTAHYDRATE

PEMETREXED DISODIUM HEPTAHYDRATE

Stock Code: 3574981
Manufacturer Part No: SML1490-50MG
Order Now for 14 day delivery
£550.18 (exc VAT) per 50MG
Quantity: - +

Application


Pemetrexed disodium heptahydrate has been used as a folate antimetabolite to study its effects on ovarian clear cell carcinoma cells. It has also been used as an antifolate to determine its effects on neuroblastoma cell lines.


Biochem/physiol Actions


Pemetrexed exhibits its activity against several tumors such as colorectal, breast, gastric, pancreatic, and cervical cancer. It acts as a substrate for multidrug resistance protein transporters.


Pemetrexed is antifolate cancer drug approved for treatment of variety of cancer including pleural mesothelioma and non-small cell lung cancer. Pemetrexed is a folate antimetabolite that inhibits thymidylate synthase, dihydrofolate reductase and glycinamide ribonucleotide formyltransferase, three enzymes used in purine and pyrimidine synthesis.


Packaging


10, 50 mg in glass bottle

Colourwhite to beige
Quality Level100
ManufacturerSIGMA-ALDRICH
Storage Temp.2-8°C
SolubilityH2O: 30 mg/mL, clear
Formpowder
Assay≥98% (HPLC)

There are no downloads for this product.