PDI inhibitor 16F16, >=98% (HPLC)

PDI inhibitor 16F16, >=98% (HPLC)

Stock Code: 3573982
Manufacturer Part No: SML0021-25MG
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Application


PDI inhibitor 16F16 has been used to inhibit PDI (protein disulfide isomerase) function to examine the functional conservation of PDIs in human embryonic kidney cells.


PDI inhibitor 16F16 may be used in protein disulfide isomerase-mediated cell signaling studies.


Biochem/physiol Actions


16F16 is a protein disulfide isomerase (PDI) inhibitor, first identified in a screen for compounds that prevent apoptosis induced by mutant huntingtin protein. 16F16 not only suppressed apoptosis induced by the misfolded protein mutant hungtingtin, it also protected rat neurons from cell death triggered by Aβ peptide. The actions of this inhibitor helped to identify a new mechanism in which a cell death pathway is regulated by protein misfolding via PDI upregulation.


Packaging


5, 25 mg in glass bottle

Colourwhite to tan
Quality Level100
InChI keyBCSIRYFYAKLJDK-UHFFFAOYSA-N
InChI1S/C16H17ClN2O3/c1-16(15(21)22-2)14-11(7-8-19(16)13(20)9-17)10-5-3-4-6-12(10)18-14/h3-6,18H,7-9H2,1-2H3
ManufacturerSIGMA-ALDRICH
SolubilityDMSO: 12 mg/mL, clear
Formpowder
Assay≥98% (HPLC)

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