Oxamflatin, >=98% (HPLC), solid

Oxamflatin, >=98% (HPLC), solid

Stock Code: 3573512
Manufacturer Part No: O3139-5MG
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Application


Oxamflatin has been used as a histone deacetylase (HDAC) inhibitor: to study its effect on specificity protein 1 (Sp1) transcription and transactivation activity and CD1d mRNA expression in various tumor cells to study its inhibitory effect on long transcript- survival motor neuron gene 2 (SMN2) silencing mediated by DNA methylation to study its effect on somatic embryogenesis in Coffea arabica thorough a miniaturized and automated screening system to study its stand-alone effect on cytarabine-sensitive and resistant cells.


Biochem/physiol Actions


Oxamflatin is an aromatic sulfonamide derivative with a hydroxamic acid group. It stimulates the expression of the transcription factor, JunD, and fibronectin. In addition, oxamflatin also aids in the morphological reversion of various NIH3T3-derived transformed cell lines. It inhibits the proliferation of various mouse and human tumor cell lines in vitro.


Histone deacetylase inhibitor; anti-cancer agent.


Features and Benefits


This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.


Packaging


1, 5 mg in glass bottle

Quality Level100
InChI keyQRPSQQUYPMFERG-LFYBBSHMSA-N
InChI1S/C17H14N2O4S/c20-17(18-21)12-5-4-7-14-8-6-9-15(13-14)19-24(22,23)16-10-2-1-3-11-16/h1-3,5-6,8-13,19,21H,(H,18,20)/b12-5+
ManufacturerSIGMA-ALDRICH
Storage Temp.2-8°C
SolubilityDMSO: soluble 13 mg/mL
Formsolid
Assay≥98% (HPLC)

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