NSCI, >=97% (HPLC), solid

NSCI, >=97% (HPLC), solid

Stock Code: 3573489
Manufacturer Part No: N1413-25MG
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£807.86 (exc VAT) per 25MG
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Application


NSCI has been used as an apoptosis inhibitor to study its effects on caspase 9 activity in cultured tick cells. It has also been used as an apoptosis inhibitor in terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) assay to study anti-CD3-induced apoptosis in the cluster of differentiation 4 (CD4+) and cluster of differentiation 8 (CD8+) T cells from pleural effusions, mononuclear cells (PEMCs).


Biochem/physiol Actions


1-(4-Methoxybenzyl)-5-[2-(pyridin-3-yl-oxymethyl)pyrrolidine-1-sulfonyl]-1H-indole-2,3-dione (NSCI) is a nonpeptide caspase 3 selective inhibitor.


Features and Benefits


This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.


Packaging


5, 25 mg in glass bottle

Quality Level100
InChI keyXDHJBIYJRNFDKS-IBGZPJMESA-N
InChI1S/C26H25N3O6S/c1-34-20-8-6-18(7-9-20)16-28-24-11-10-22(14-23(24)25(30)26(28)31)36(32,33)29-13-3-4-19(29)17-35-21-5-2-12-27-15-21/h2,5-12,14-15,19H,3-4,13,16-1
ManufacturerSIGMA-ALDRICH
SolubilityDMSO: >10 mg/mL, H2O: insoluble
Formsolid
Assay≥97% (HPLC)

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