NSC756093

Descriptions

Biochem/physiol Actions

NSC756093, a podophyllotoxin analog, is a potent and specific inhibitor of GBP1:PIM1 interaction that inhibits proliferation of paclitaxel resistant cancer cells. Apparently, NSC756093 stabilizes a conformation of GBP1 not suitable for binding to PIM1.

Packaging

5, 25 mg in glass bottle

Specifications

Colour	white to beige
Quality Level	100
InChI key	SMEJQLRLHKWIFV-UHFFFAOYSA-N
InChI	1S/C20H19NO4/c1-24-14-7-8-15-16(11-14)21(9-10-22)17-12-25-20(23)19(17)18(15)13-5-3-2-4-6-13/h2-8,11,18,22H,9-10,12H2,1H3
Manufacturer	SIGMA-ALDRICH
Solubility	DMSO: 10 mg/mL, clear
Form	powder
Assay	≥98% (HPLC)