NSC130813
Biochem/physiol Actions
NSC130813 blocks protein-protein interactions between XPF and ERCC1, two proteins involved in nucleotide excision repair (NER). The compound, NSC130813, blocks repair of DNA damage induced by platinum-based ctyotoxic drugs and DNA alkylating agents. NSC130813 synergistically potentiates cell death in cancer cell lines treated with cisplatin or mitomycin C.
Other Notes
air sensitive
Packaging
5, 25 mg in glass bottle
| Colour | yellow to orange |
|---|---|
| Quality Level | 100 |
| Manufacturer | SIGMA-ALDRICH |
| Storage Temp. | −20°C |
| Solubility | H2O: 10 mg/mL, clear |
| Form | powder |
| Assay | ≥98% (HPLC) |
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