NMDI14 97% (HPLC)

NMDI14 97% (HPLC)

Stock Code: 3575051
Manufacturer Part No: SML1538-5MG
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£164.36 (exc VAT) per 5MG
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Application


NMDI14 has been used as a nonsense-mediated mRNA decay (NMD) inhibitor:to study its effects on differentiating cardiomyocytesto study its effects on zebrafish pdzk1 gene-knockout embryosto analyze its effects on the apoptosis of colorectal cancer cells


Biochem/physiol Actions


NMDI14 is a potent nonsense-mediated RNA decay (NMD) inhibitor. NMDI14 targets a pocket in the SMG7 protein and disrupts SMG7–UPF1 interactions. NMDI14 restores of full-length p53 protein activity in in cells with premature termination codons (PTC) mutated p53.


Packaging


5, 25 mg in glass bottle

Colourwhite to beige
Quality Level100
ManufacturerSIGMA-ALDRICH
Storage Temp.2-8°C
SolubilityDMSO: 0.2 mg/mL, clear (warmed)
Formpowder
Assay≥97% (HPLC)

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