NMDI14 97% (HPLC)
Application
NMDI14 has been used as a nonsense-mediated mRNA decay (NMD) inhibitor:to study its effects on differentiating cardiomyocytesto study its effects on zebrafish pdzk1 gene-knockout embryosto analyze its effects on the apoptosis of colorectal cancer cells
Biochem/physiol Actions
NMDI14 is a potent nonsense-mediated RNA decay (NMD) inhibitor. NMDI14 targets a pocket in the SMG7 protein and disrupts SMG7–UPF1 interactions. NMDI14 restores of full-length p53 protein activity in in cells with premature termination codons (PTC) mutated p53.
Packaging
5, 25 mg in glass bottle
| Colour | white to beige |
|---|---|
| Quality Level | 100 |
| Manufacturer | SIGMA-ALDRICH |
| Storage Temp. | 2-8°C |
| Solubility | DMSO: 0.2 mg/mL, clear (warmed) |
| Form | powder |
| Assay | ≥97% (HPLC) |
There are no downloads for this product.
