NKH 477, >=98% (HPLC), powder
Biochem/physiol Actions
NKH 477 is a potent, orally active adenylyl cyclase activator. It is a water soluble derivative of forskolin, and dose dependentyl increases cAMP and blocks potassium-induced contraction concetrations in smooth muscle strips (IC50 = 80 nM). NKH 477 causes relaxation of histamine treated guinea pig smooth muscle (IC50 = 32 nM).
Features and Benefits
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Packaging
5, 25 mg in glass bottle
Preparation Note
A clear to slightly hazy solution is possible.
| Colour | white to beige |
|---|---|
| Quality Level | 100 |
| InChI key | VIRRLEDAYYYTOD-YHEOSNBFSA-N |
| InChI | 1S/C27H43NO8.ClH/c1-10-24(5)15-18(31)27(33)25(6)17(30)11-13-23(3,4)21(25)20(35-19(32)12-14-28(8)9)22(34-16(2)29)26(27,7)36-24;/h10,17,20-22,30,33H,1,11-15H2,2- |
| Manufacturer | SIGMA-ALDRICH |
| Solubility | H2O: 3 mg/mL, clear to slightly hazy (warmed) |
| Form | powder |
| Assay | ≥98% (HPLC) |
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