NIMORAZOLE
Biochem/physiol Actions
Nimorazole is a nitroimidazole-based hypoxic cell-radiation sensitizer with less toxicity than etanidazole or misonidazole. Under low oxygen (hypoxic) condition, reductive activation of its 5-nitroimidazole moiety leads to enhanced adduct formation with reduced glutathione, which form the basis of cancer/tumour-selective radiation sensitization. Nimorazole is also a known anti-infective agent against trichomoniasis, an infectious disease caused by the protozoan parasite Trichomonas vaginalis.
| Colour | white to beige |
|---|---|
| Quality Level | 100 |
| InChI key | MDJFHRLTPRPZLY-UHFFFAOYSA-N |
| InChI | 1S/C9H14N4O3/c14-13(15)9-7-10-8-12(9)2-1-11-3-5-16-6-4-11/h7-8H,1-6H2 |
| Manufacturer | SIGMA-ALDRICH |
| Storage Temp. | 2-8°C |
| Solubility | DMSO: 30 mg/mL, clear |
| Form | powder |
| Assay | ≥98% (HPLC) |
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