NG25 TRIHYDROCHLORIDE

NG25 TRIHYDROCHLORIDE

Stock Code: 3574761
Manufacturer Part No: SML1332-5MG
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£224.25 (exc VAT) per 5MG
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Application


NG25 trihydrochloride has been used as a transforming growth factor ? (TGF?)-activated kinase 1 inhibitor (TAK1) in human umbilical vein endothelial cells (HUVECs) and pulmonary artery smooth muscle cells.


Biochem/physiol Actions


NG25 is potent multiple kinase inhibitor belonging to type II kinase inhibitors class that binds to kinase ATP binding pocket at not ready to catalyze conformation. NG25 is used as a potent dual inhibitor of TAK1 (TGFβ-Activated Kinase 1, MAP3K7) and MAP4K2 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2; GCK) kinases. NG25 inhibits the activation of IKKa/IKKb and prevents the secretion of type 1 IFNs by TLR2 and TLR9 agonist.


Other Notes


Light sensitive


Packaging


5, 25 mg in glass bottle

Colourwhite to beige
Quality Level100
InChI keySMPGEBOIKULBCT-UHFFFAOYSA-N
InChI1S/C29H30F3N5O2/c1-3-36-12-14-37(15-13-36)18-21-6-7-22(17-24(21)29(30,31)32)35-28(38)20-5-4-19(2)26(16-20)39-25-9-11-34-27-23(25)8-10-33-27/h4-11,16-17H,3,12-1
ManufacturerSIGMA-ALDRICH
SolubilityH2O: 5 mg/mL, clear
Formpowder
Assay≥98% (HPLC)

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