NELARABINE

Descriptions

Biochem/physiol Actions

Nelarabine is an antineoplastic purine nucleoside analog used in T-cell acute lymphoblastic leukemia. It is a pro-drug of Ara-G, which is converted by cellular kinases to the active 5′-triphosphate, Ara-GTP. Incorporation of Ara-GTP into DNA leads to inhibition of DNA synthesis and apoptosis.

Packaging

10, 50 mg in glass bottle

Specifications

Colour	white to beige
Quality Level	100
InChI key	IXOXBSCIXZEQEQ-KBNQYOMWSA-N
InChI	1S/C11H15N5O5/c1-20-9-5-8(14-11(12)15-9)16(3-13-5)10-7(19)6(18)4(2-17)21-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2,12,14,15)/t4-,6-,7+,10?/m1/s1
Manufacturer	SIGMA-ALDRICH
Solubility	H2O: 5 mg/mL, clear (warmed)
Form	powder
Assay	≥98% (HPLC)