Nalpha-Methylhistamine dihydrochloride, (The product is pure based on elemental analysis results, NM

Nalpha-Methylhistamine dihydrochloride, (The product is pure based on elemental analysis results, NM

Stock Code: 3573398
Manufacturer Part No: H5914-10MG
Order Now for 7 day delivery
£200.57 (exc VAT) per 10MG
Quantity: - +

Biochem/physiol Actions


N?-Methylhistamine dihydrochloride helps in removing or decreasing the headache in migraine prophylaxis. It is highly effective than histamine in inducing cyclic adenosine 3?,5?-monophosphate (cAMP) synthesis.


Production of N-alpha-methyl-histamine (NAMH), a histamine H(3) receptor (H3R) agonist, is promoted in Helicobacter pylori infected human gastric mucosa. NAMH acts directly on histamine H(2) receptors (H2Rs) in animals to stimulate acid secretion and to be a H2R agonist. NAMH dose dependently stimulated cAMP productions in CHO-H2R cells. This production was inhibited by famotidine but not by thioperamide. Control CHO cells were unresponsive to either histamine or NAMH. In addition, the effect of NAMH, in terms of cAMP production in CHO-H2R cells, was more potent than that of histamine-that is, with a lower EC50 concentration and higher maximal cAMP production. Both NAMH and histamine, but not R-alpha-methyl-histamine, effectively inhibited [(3)H] tiotidine binding to CHO-H2R cells. These results confirm that NAMH, which is produced in the gastric mucosa by H pylori, is a potent H2R agonist as well as a H3R agonist.


Features and Benefits


This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.


Packaging


10, 50 mg in glass bottle


Quality


The product is pure based on elemental analysis results, NMR and MS spectra.

Colourwhite
Quality Level100
InChI keyAYUQICXJAMPXPF-UHFFFAOYSA-N
InChI1S/C6H11N3.2ClH/c1-7-3-2-6-4-8-5-9-6;;/h4-5,7H,2-3H2,1H3,(H,8,9);2*1H
ManufacturerSIGMA-ALDRICH
Storage Temp.2-8°C
SolubilityH2O: >20 mg/mL
Formsolid

There are no downloads for this product.