MoTP, >=98% (HPLC)
Application
MoTP may be used in cell signaling and differentiation studies.
Biochem/physiol Actions
MoTP (also known as 33N14) reversibly blocks the specification of neural crest cells into melanocytes in zebrafish studies. Differentiation of neural crest cell-derived melanoblasts proceeds to late developmental stages, but they fail to reach the terminal stage of melanin production and die. Melanocytotoxicity is dependent on tyrosinase activity which convert it into a toxic form. MoTP specifically ablates only cells that express tyrosinase at high levels, which in the embryo are limited to melanoblasts and newly formed melanocytes. MoTP should be a useful tool for elucidating melanocyte stem cell regeneration, recruitment, and maintenance.
Packaging
5, 25 mg in glass bottle
| Colour | white to tan |
|---|---|
| Quality Level | 100 |
| InChI key | YHKNLUTUXZDOQI-UHFFFAOYSA-N |
| InChI | 1S/C14H21NO2S/c16-13-3-5-14(6-4-13)18-12-2-1-7-15-8-10-17-11-9-15/h3-6,16H,1-2,7-12H2 |
| Manufacturer | SIGMA-ALDRICH |
| Solubility | DMSO: ≥80 mg/mL |
| Form | powder |
| Assay | ≥98% (HPLC) |
There are no downloads for this product.
