Application
Madrasin has been used as a spliceosome inhibitor to inhibit pre-mRNA processing in 3T3-L1 cells.
Biochem/physiol Actions
Madrasin is a potent and cell penetrant splicing inhibitor that interferes with the early stages of spliceosome assembly. Madrasin stalls spliceosome assembly at the A complex.
Madrasin is considered toxic to the cell at a higher concentration. At its minimal concentration, madrasin is known to induce subnuclear protein localization and cause cell cycle arrest.
Packaging
5, 25 mg in glass bottle
| Colour | , white to dark brown |
|---|---|
| Quality Level | 100 |
| InChI key | QQJIYKXTEMDJFM-UHFFFAOYSA-N |
| InChI | 1S/C16H17N5O2/c1-8-9(2)17-16(20-14(8)22)21-15-18-10(3)12-6-5-11(23-4)7-13(12)19-15/h5-7H,1-4H3,(H2,17,18,19,20,21,22) |
| Manufacturer | SIGMA-ALDRICH |
| Solubility | DMSO: 0.5 mg/mL, clear (warmed) |
| Form | powder |
| Assay | ≥98% (HPLC) |
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