LY2090314

LY2090314

Stock Code: 3574908
Manufacturer Part No: SML1438-25MG
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Biochem/physiol Actions


LY2090314 is a potent and selective ATP-competitive inhibitor of Glycogen synthase kinase-3 (GSK-3) currently in clinical trials for cancer therapy. LY2090314 has IC50 values of 1.5 nM and 0.9 nM for GSK-3α and GSK-3β, respectively.


LY2090314 can decrease the development of human MYCN amplified and non-amplified neuroblastoma (NB) cell lines in vitro. It has the ability to prevent the multiplication, colony formation and cell confluency of neuroblastoma.


Packaging


5, 25 mg in glass bottle

Colouryellow to orange
Quality Level100
InChI keyHRJWTAWVFDCTGO-UHFFFAOYSA-N
InChI1S/C28H25FN6O3/c29-18-12-17-15-34(28(38)32-7-3-1-4-8-32)11-10-33-16-20(19(13-18)25(17)33)23-24(27(37)31-26(23)36)21-14-30-22-6-2-5-9-35(21)22/h2,5-6,9,12-14,16
ManufacturerSIGMA-ALDRICH
Formpowder
Assay≥98% (HPLC)

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