Lomerizine dihydrochloride, >=98% (HPLC), powder

Lomerizine dihydrochloride, >=98% (HPLC), powder

Stock Code: 3573441
Manufacturer Part No: L6295-10MG
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£143.46 (exc VAT) per 10MG
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Biochem/physiol Actions


Lomerizine dihydrochloride is a voltage-dependent calcium channel blocker and selective cerebral vasodilator. It is one of the most selective calcium channel blockers for the CNS and cerebral arteries. It has been reported to inhibit both T-type and L-type Ca2+ currents in rat hippocampal CA1 pyramidal neurons, to prevent glutamate-induced neurotoxicity in rat hippocampal primary cell cultures, and to exhibit protective effects in animal models of migraine, ischemia and hypoxia. In Japan, lomerizine has been used as the first-line prophylactic drug for migraines.


Packaging


10, 50 mg in glass bottle

Colourwhite to tan
Quality Level100
InChI keyLOGVKVSFYBBUAJ-UHFFFAOYSA-N
InChI1S/C27H30F2N2O3.2ClH/c1-32-24-13-8-21(26(33-2)27(24)34-3)18-30-14-16-31(17-15-30)25(19-4-9-22(28)10-5-19)20-6-11-23(29)12-7-20;;/h4-13,25H,14-18H2,1-3H3;2*1H
ManufacturerSIGMA-ALDRICH
SolubilityDMSO: ≥30 mg/mL
Formpowder
Assay≥98% (HPLC)

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