LIXIVAPTAN
Biochem/physiol Actions
Arginine vasopressin (AVP) plays an important part in circulatory and water homoeostasis and is important in renal hemodynamic alterations, water retention, and cardiac remodeling in congestive heart failure (CHF). Lixivaptan is an AVP V2-receptor selective antagonist that increases water excretion and normalizes serum sodium levels. Lixivaptan has been in clinical trials for hyponatremia associated with heart failure.
Packaging
5, 25 mg in glass bottle
| Colour | white to beige |
|---|---|
| Quality Level | 100 |
| InChI key | PPHTXRNHTVLQED-UHFFFAOYSA-N |
| InChI | 1S/C27H21ClFN3O2/c1-17-8-9-19(29)13-23(17)26(33)30-20-10-11-22(24(28)14-20)27(34)32-16-21-6-4-12-31(21)15-18-5-2-3-7-25(18)32/h2-14H,15-16H2,1H3,(H,30,33) |
| Manufacturer | SIGMA-ALDRICH |
| Further Info | 4% w/w in ethyl acetate |
| Solubility | DMSO: 20 mg/mL, clear |
| Form | powder |
| Assay | ≥96% (HPLC) |
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